Balmus Laboratory




Balmus G, Pilger D et al. (2019) ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks. Nature Communications 10 (87)


Dev H et al. (2018) - Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells. Nature Cell Biology 20: 954  

Balmus G, Larrieu D et al. (2018) - Targeting NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome. Nature communications 9 (1), 1700  


Trigg B, Lauer K, Fernandes dos Santos P, Coleman H., Balmus G, Mansur G, Ferguson B (2017) The non-homologous end joining protein PAXX acts to restrict HSV-1 infection. Viruses 9 (11), 342 full text


Balmus G, Barros AC, Wijnhoven PWG, Lescale C, Hasse HL, Boroviak K, et al. (2016) Synthetic lethality between PAXX and XLF in mammalian development. Genes & Dev. 30:2152-2157

Lescale C, Hasse HL, Blackford AN, Balmus G, Bianchi JJ, Yu W, et al. (2016) Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination. Cell Reports 16(11), 2967-2997

Subbaramaiah K, Brown KA, Zahid H, Balmus G, Weiss RS, Herbert B, Dannenberg AJ (2016) Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells. The Journal of Biological Chemistry 291, 16011-16023.

McIntyre RE, Nicod J, Robles-Espinoza CD, Maciejowski J, Cai N, Hill J, Verstraten R, Iyer V, Rust AG, Balmus G, Mott R, Flint J, Adams DJ (2016) A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice. G3 6, 82343-2354

Balmus G, Lim PX, Oswald A, Hume KR, Cassano A, Pierre J, et al. (2016) HUS1 regulates in vivo responses to genotoxic chemotherapies. Oncogene 35: 662–669


Balmus G, Karp NA, Ng BL, Jackson SP, Adams DJ and McIntyre RE (2015) A high-throughput in vivo micronucleus assay for genome stability screening in the mouse. Nature protocols 10(1): 205-215


Balmus G, and McIntyre RE. (2014). Genetic screens in mice for genome integrity maintenance and cancer predisposition. Curr. Opin. Genet. Dev. 24: 1–7.

Okayama S, Kopelovich L, Balmus G, Weiss RS, Herbert B-S, Dannenberg AJ, et al. (2014). p53 Protein Regulates Hsp90 ATPase Activity and Thereby Wnt Signaling by Modulating Aha1 Expression. Journal of Biological Chemistry 289: 6513–6525.


Balmus G, Zhu M, Mukherjee S, Lyndaker AM, Hume KR, Lee J, et al. (2012). Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1. Human molecular genetics 21: 3408–3420.

Daugherity EK, Balmus G, Saei AA, Moore ES, Abdallah DA, Rogers AB, et al. (2012). The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease. Cell Cycle 11: 1918–1928.

Qi Q, Huang W, Bai Y, Balmus G, Weiss RS, and August A. (2012). A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice. J Immunol 188: 3611–3619.


Holloway JK, Mohan S, Balmus G, Sun X, Modzelewski A, Borst PL, et al. (2011). Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis. PLoS Genet. 7: e1002094

Jinadasa R, Balmus G, Gerwitz L, Roden J, Weiss R, and Duhamel G. (2011). Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice. Journal of Visualized Experiments 50:2598.


Balmus G, Trifonov VA, Biltueva LS, O'Brien PC, Alkalaeva ES, Fu B, et al. (2007). Cross-species chromosome painting among camel, cattle, pig and human: further insights into the putative Cetartiodactyla ancestral karyotype. Chromosome Research 15: 499–514.


Di Berardino D, Nicodemo D, Coppola G, King AW, Ramunno L, Cosenza GF, Iannuzzi L, Di Meo GP, Balmus G, and Rubes J. (2006). Cytogenetic characterization of alpaca (Lama pacos, fam. Camelidae) prometaphase chromosomes. Cytogenetic and Genome Research 115: 138–144.

Basset P, Yannic G, Yang F, O'Brien PCM, Graphodatsky AS, Ferguson-Smith MA, Balmus G, Volobouev VT, and Hausser J. (2006). Chromosome localization of microsatellite markers in the shrews of the Sorex araneus group. Chromosome Research 14: 253–262.


Carlan M, Carlan AF and Balmus G (2004). Clonal evolution of a mouse metastatic hemangiosarcoma. Analele Stiintifice ale Universitatii" Alexandru Ioan Cuza" din Iasi Sec. II a. Genetica si Biologie Moleculara 5.1.